Article

<i>ATAD1</i> Overexpression Enhances Mitochondrial and Peroxisomal Function in Zellweger Syndrome Disorder Models

2025-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Zellweger Spectrum Disorders (ZSDs) are caused by mutations in any of the different peroxin (PEX) genes, which are essential for peroxisome biogenesis and function. Clinical features of ZSDs include seizures, leukodystrophy, renal and liver dysfunction, skeletal abnormalities, and they usually result in death during infancy or early childhood. There are no treatments for ZSDs, and their rarity,...

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Literature Corpus work: bca38296-dc34-5ba9-859b-0168287105f8
DOI: 10.1101/2025.10.14.682039

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