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Article

ALYREF inhibits ferroptosis in vascular endothelial cells and improves atherosclerosis by epigenetic modification of CISD1

24 Sept 2025

Abstract excerpt

Atherosclerosis (AS) is a disease marked by lipid metabolism dysfunction. Methylation of 5-methylcytosine (m5C) mRNA can regulate AS progression. We investigated the role and mechanism of m5C reader ALYREF in AS. ApoE−/− mice AS models were constructed. Oil Red O staining evaluated the degree of aortic plaque. Serum LDL and TG levels were assessed. ELISA detected vascular inflammation and ATP production....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40993735
DOI: 10.1186/s13148-025-01955-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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