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Article

Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.

EMBO molecular medicine - 1 Aug 2013

Chang Yi-Cheng, Yu Yu-Hsiang, Shew Jin-Yuh, Lee Wei-Jei, Hwang Juey-Jen, Chen Yen-Hui, Chen Yet-Ran, Wei Pei-Chi, Chuang Lee-Ming, Lee Wen-Hwa

Abstract excerpt

Elevated oxidative stress is closely associated with obesity. Emerging evidence shows that instead of being a consequence of obesity, oxidative stress may also contribute to fat formation. Nonselenocysteine-containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) is a conserved oxidative stress sensor/transducer and deficiency of NPGPx causes accumulation of reactive oxygen species (ROS). In this...

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Identifiers

PMID: 23828861
DOI: 10.1002/emmm.201302679
PMCID: PMC3944459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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