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Estrogen-Induced Cell Cycle Arrest and Apoptosis as an Unexpected Outcome of Aromatase Inhibitor-Resistance in ER+ Breast Cancer

2021-02-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Estrogen is known to promotes hormone-dependent breast cancer through activation of estrogen receptor (ER)-α encoded by <italic>ESR1</italic>. However, several clinical trials reported the unexpected therapeutic benefit of E2 for aromatase inhibitor (AI)-resistant cases of ER<sup>+</sup> breast cancer. Considering potential impact of such clinical observation, w...

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Literature Corpus work
08efc722-e95e-5448-85bd-cea25e7eeacd
DOI
10.21203/rs.3.rs-236742/v1
Open publication

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