Article

Molecular Mechanisms and Therapeutic Strategies to Overcome Resistance to Endocrine Therapy and CDK4/6 Inhibitors in Advanced ER+/HER2- Breast Cancer

2025-03-18

Abstract excerpt

Approximately 70–80% of breast cancers are ER+ and 65% of them also are ER+PR+. In most cases of ER+ advanced disease, endocrine therapy (ET) is the initial treatment with different drugs that act by inhibiting the ER signaling, mainly tamoxifen, a selective estrogen receptor modulator (SERM), or fulvestrant, a selective estrogen receptor degrader (SERD), or by impeding the estrogen formation as aromatase in...

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Literature Corpus work: ab946e65-ef4b-531a-84a3-1ec3984c989b
DOI: 10.20944/preprints202503.1305.v1

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