Article

Cell cycle S-phase arrest drives cell extrusion

2019-11-13

Abstract excerpt

<h4>SUMMARY</h4> Cell extrusion is a process of cell elimination in which a cell is squeezed out from its tissue of origin. Extrusion occurs in organisms as diverse as sponges, nematodes, insects, fish and mammals. Defective extrusion is linked to many epithelial disorders, including cancer. Despite broad occurrence, cell-intrinsic triggers of extrusion conserved across phyla are generally unknown. We combined ge...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7a0e82be-6bd8-5511-a3eb-aecfe8384760
DOI: 10.1101/839845

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell cycle S-phase arrest drives cell extrusionDOI 10.1101/839845Read

Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo.Semantic proximity Read

Basal extrusion drives cell invasion and mechanical stripping of E-cadherinSemantic proximity Read

Apical PAR complex proteins protect against programmed epithelial assaults to create a continuous and functional intestinal lumenSemantic proximity Read

Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegansSemantic proximity Read

The endoplasmic reticulum promotes microtubule organization and region-specific disassembly to execute Compartmentalized Cell EliminationSemantic proximity Read

Epidermal cell fusion promotes the transition from an embryonic to a larval transcriptome in C. elegans.Semantic proximity Read

Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway.Semantic proximity Read

A reevaluation of the relationship between EGL-43 (EVI1/MECOM) and LIN-12 (Notch) during <i>C. elegans</i> anchor cell invasionSemantic proximity Read

Essential embryonic roles of the CKI-1 cyclin-dependent kinase inhibitor in cell-cycle exit and morphogenesis in C elegans.Semantic proximity Read

Premature endocycling of <i>Drosophila</i> follicle cells causes pleiotropic defects in oogenesisSemantic proximity Read

Specific roles for the GATA transcription factors end-1 and end-3 during C. elegans E-lineage development.Semantic proximity Read

Programmed elimination of cells by caspase-independent cell extrusion in C. elegans.Semantic proximity Read