Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway.

Abstract excerpt

To maintain an intact barrier, epithelia eliminate dying cells by extrusion. During extrusion, a cell destined for apoptosis signals its neighboring cells to form and contract a ring of actin and myosin, which squeezes the dying cell out of the epithelium. Here, we demonstrate that the signal produced by dying cells to initiate this process is sphingosine-1-phosphate (S1P). Decreasing S1P synthesis by inhibiting...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Actomyosin
• Share to Enzyme Inhibitors
• Share to Epithelial Cells