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Article

Grhl3 promotes retention of epidermal cells under endocytic stress to maintain epidermal architecture in zebrafish.

PLoS genetics - 1 Sept 2021

Phatak Mandar, Kulkarni Shruti, Miles Lee B, Anjum Nazma, Dworkin Sebastian, Sonawane Mahendra

Abstract excerpt

Epithelia such as epidermis cover large surfaces and are crucial for survival. Maintenance of tissue homeostasis by balancing cell proliferation, cell size, and cell extrusion ensures epidermal integrity. Although the mechanisms of cell extrusion are better understood, how epithelial cells that round up under developmental or perturbed genetic conditions are reintegrated in the epithelium to maintain homeostasis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34570762
DOI: 10.1371/journal.pgen.1009823
PMCID: PMC8496789

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