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Article

Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.

PLoS genetics - 1 Jan 2012

Chen Rong, Corona Erik, Sikora Martin, Dudley Joel T, Morgan Alex A, Moreno-Estrada Andres, Nilsen Geoffrey B, Ruau David, Lincoln Stephen E, Bustamante Carlos D, Butte Atul J

Abstract excerpt

Many disease-susceptible SNPs exhibit significant disparity in ancestral and derived allele frequencies across worldwide populations. While previous studies have examined population differentiation of alleles at specific SNPs, global ethnic patterns of ensembles of disease risk alleles across human diseases are unexamined. To examine these patterns, we manually curated ethnic disease association data from 5,065...

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Identifiers

PMID: 22511877
DOI: 10.1371/journal.pgen.1002621
PMCID: PMC3325177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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