Inbreeding and risk of late onset complex disease

Abstract excerpt

N From arguments derived from population genetics, we propose that the genetic basis of common late onset diseases includes a major class of deleterious recessive alleles. Inbreeding is therefore predicted to increase the incidence of such diseases. N Among 10 late onset conditions studied in a genetic isolate population, inbreeding was found to be a significant (positive) predictor for coronary heart disease,...

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