Article

CIDEC gene silencing alleviates pulmonary vascular remodeling induced by type 2 diabetes by regulating endothelial mitochondrial function

2026-05-13

Abstract excerpt

<title>Abstract</title> <p> <bold>Introduction:</bold> Metabolic syndrome, especially type 2 diabetes and insulin resistance, was significantly associated with pulmonary hypertension independently. Mitochondrial dysfunction plays an important role in the pathophysiological process of pulmonary vascular remodeling, including endothelial dysfunction, smooth muscle cell proliferation and collagen deposition, etc....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 08c4f4ad-1d09-5183-80eb-35716fe2177d
DOI: 10.21203/rs.3.rs-9281014/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CIDEC gene silencing alleviates pulmonary vascular remodeling induced by type 2 diabetes by regulating endothelial mitochondrial functionDOI 10.21203/rs.3.rs-9281014/v1Read

GDF11 alleviates pathological myocardial remodeling in diabetic cardiomyopathy through SIRT1-dependent regulation of oxidative stress and apoptosisSemantic proximity Read

Adjusted vascular contractility relies on integrity of progranulin pathway: Insights into mitochondrial functionSemantic proximity Read

Prohibitin overexpression improves myocardial function in diabetic cardiomyopathySemantic proximity Read

LncRNA MFRL regulates the phenotypic switch of vascular smooth muscle cells to attenuate arterial remodeling by encoding a novel micropeptide MFRLP.Semantic proximity Read

Canagliflozin alleviates pulmonary hypertension partially by inhibition of PPARγ S225 phosphorylation and PPARγ-mediated suppression of oxidative stressSemantic proximity Read

Arterial remodeling: the role of mitochondrial metabolism in vascular smooth muscle cells.Semantic proximity Read

The Key Laboratory of Pulmonary Vascular Medicine, Chinese Academy of Medical Sciences (KLPVM-CAMS).Semantic proximity Read

Mitochondrial Dysfunction in Endothelial Cells Drives Greater Vascular Impairment in Females with Diabetes-Associated Peripheral Artery DiseaseSemantic proximity Read

From the Cover: Lung-Specific Overexpression of Constitutively Active IKK2 Induces Pulmonary and Systemic Inflammations but Not Hypothalamic Inflammation and Glucose Intolerance.Semantic proximity Read

Caveolin 1 Reduces High Glucose-Induced Hypertrophy and Inflammatory Fibrosis of H9C2 Cardiomyocytes By Inhibiting NF-κB SignalingSemantic proximity Read

Endothelial β3-Adrenergic Receptor activation prevents pulmonary hypertensionSemantic proximity Read

SIRT3 Represses Vascular Remodeling via Reducing Mitochondrial Ac-CoA Accumulation in Vascular Smooth Muscle Cells.Semantic proximity Read