Article

Canagliflozin alleviates pulmonary hypertension partially by inhibition of PPARγ S225 phosphorylation and PPARγ-mediated suppression of oxidative stress

2023-04-20

Abstract excerpt

<title>Abstract</title><p>Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a new anti-diabetic agent, has been found to have remarkable cardiovascular benefits. However, it remains unknown whether CANA is beneficial in vascular pathology of PH. Therefore, our study aims to investigate the role and pharmacological mechanism of CANA in treating PH. Firstly, CANA suppress...

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Literature Corpus work: b04588fa-b10e-590e-abac-7cd815339c76
DOI: 10.21203/rs.3.rs-2801796/v1

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