Article

GDF11 alleviates pathological myocardial remodeling in diabetic cardiomyopathy through SIRT1-dependent regulation of oxidative stress and apoptosis

2021-03-31

Abstract excerpt

<title>Abstract</title> <p>Background Diabetic cardiomyopathy (DCM) is characterized by cardiac dysfunction and cardiomyocyte injury, which induced by metabolic disorder. Nowadays, there is still a lack of drugs for the treatment of DCM. Growth differentiation factor 11 (GDF11) is a novel member of the transforming growth factor β superfamily that alleviates cardiac hypertrophy, myocardial infarction, and vascul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e23d12c-b990-5cec-9212-86011d5dc6c4
DOI: 10.21203/rs.3.rs-357210/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GDF11 alleviates pathological myocardial remodeling in diabetic cardiomyopathy through SIRT1-dependent regulation of oxidative stress and apoptosisDOI 10.21203/rs.3.rs-357210/v1Read

Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathySemantic proximity Read

KLF15 Negatively Regulates Cardiac Fibrosis and SDF-1β Attenuates Cardiac Fibrosis Through KLF15 Pathway in Type 2 Diabetic MiceSemantic proximity Read

Novel Insights Into the Pathogenesis of Diabetic Cardiomyopathy and Pharmacological StrategiesSemantic proximity Read

Novel Oral-edaravone Attenuates Diastolic Dysfunction of Diabetic Cardiomyopathy via Activating the Nrf2 Signaling PathwaySemantic proximity Read

Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction.Semantic proximity Read

Caveolin 1 Reduces High Glucose-Induced Hypertrophy and Inflammatory Fibrosis of H9C2 Cardiomyocytes By Inhibiting NF-κB SignalingSemantic proximity Read

Molecular Mechanisms and Epigenetic Regulation in Diabetic CardiomyopathySemantic proximity Read

Role of microRNAs in the pathogenesis of diabetic cardiomyopathySemantic proximity Read

Analysis of differentially expressed genes related to the development of diabetic cardiomyopathy in the myocardium of type-2 diabetic ratsSemantic proximity Read

Prohibitin overexpression improves myocardial function in diabetic cardiomyopathySemantic proximity Read

Epigenetic Down-Regulation of Sirt 1 via DNA Methylation and Oxidative Stress Signaling Contributes to the Gestational Diabetes Mellitus-Induced Fetal Programming of Heart Ischemia-Sensitive Phenotype in Late LifeSemantic proximity Read

The stress-responsive protein REDD1 drives diabetic myocardial injury via activation of autophagy-dependent ferroptosisSemantic proximity Read