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Article

Anemoside A3 activates TLR4-dependent M1-phenotype macrophage polarization to represses breast tumor growth and angiogenesis.

Toxicology and applied pharmacology - 1 Dec 2021

Yin Li, Fan Zeping, Liu Peng, Chen Lanying, Guan Ziyi, Liu Yahui, Luo Yingying

Abstract excerpt

The polarization of macrophages has been previously demonstrated to be closely related to immune and inflammatory processes in the tumorigenesis and progression of breast cancer. In the present study, Anemoside A3 (A3), an active compound from Pulsatilla saponins, was screened out and polarized M0 macrophages into the classically activated macrophages (M1-phenotype). We found that A3 is an activator of...

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PMID: 34673087
DOI: 10.1016/j.taap.2021.115755

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