Article

Tensor Decomposition of Stimulated Monocyte and Macrophage Gene Expression Profiles Identifies Neurodegenerative Disease-specific <i>Trans</i> -eQTLs

2018-12-18

Abstract excerpt

Recent human genetic studies suggest that cells of the innate immune system have a primary role in the pathogenesis of neurodegenerative diseases. However, the results from these studies often do not elucidate how the genetic variants affect the biology of these cells to modulate disease risk. Here, we applied a tensor decomposition method to uncover disease-associated gene networks linked to distal genetic variat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 088d50ac-dd17-5b56-bf24-248bf020c6cd
DOI: 10.1101/499509

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tensor Decomposition of Stimulated Monocyte and Macrophage Gene Expression Profiles Identifies Neurodegenerative Disease-specific <i>Trans</i> -eQTLsDOI 10.1101/499509Read

Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs.Semantic proximity Read

Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.Semantic proximity Read

Tensor decomposition for multiple-tissue gene expression experiments.Semantic proximity Read

Phenotypes associated with genetic determinants of type I interferon regulation in the UK Biobank: a protocolSemantic proximity Read

Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’sSemantic proximity Read

Phenotypes associated with genetic determinants of type I interferon regulation in the UK Biobank: a protocolSemantic proximity Read

Early Detection of Neurological Dysfunction Using Blood Cell Transcript ProfilesSemantic proximity Read

Tensor decomposition of multi-dimensional splicing events across multiple tissues to identify splicing-mediated risk genes associated with complex traits.Semantic proximity Read

A monocyte gene expression signature in the early clinical course of Parkinson’s diseaseSemantic proximity Read

PRISMA: A tensor-based framework for deconstructing the genetic architecture of complex diseases, with application to diabetic retinopathySemantic proximity Read

Tensor decomposition reveals coordinated multicellular patterns of transcriptional variation that distinguish and stratify disease individualsSemantic proximity Read

Constructing endophenotypes of complex diseases using non-negative matrix factorization and adjusted rand index.Semantic proximity Read