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Article

Tensor decomposition of multi-dimensional splicing events across multiple tissues to identify splicing-mediated risk genes associated with complex traits.

PLoS computational biology - 1 Jul 2025

Yan Yan, Chen Rui, Kang Hakmook, Tan Yuting, Tiwari Anshul, Ma Siyuan, Wen Zhexing, Zhong Xue, Li Bingshan

Abstract excerpt

Identifying risk genes associated with complex traits remains challenging. Integrating gene expression data with Genome-Wide Association Study (GWAS) through Transcriptome-Wide Association Study (TWAS) methods has discovered candidate risk genes for various complex traits. Splicing, which explains a comparable heritability of complex traits as gene expression, is under-explored due to its multidimensionality. To...

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Identifiers

PMID: 40690510
DOI: 10.1371/journal.pcbi.1013303
PMCID: PMC12303388

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