Article
Single-cell RNA-seq analysis reveals the progression of human osteoarthritis.
Annals of the rheumatic diseases - 1 Jan 2019
Ji Quanbo, Zheng Yuxuan, Zhang Guoqiang, Hu Yuqiong, Fan Xiaoying, Hou Yu, Wen Lu, Li Li, Xu Yameng, Wang Yan, Tang Fuchou
Abstract excerpt
OBJECTIVES: Understanding the molecular mechanisms underlying human cartilage degeneration and regeneration is helpful for improving therapeutic strategies for treating osteoarthritis (OA). Here, we report the molecular programmes and lineage progression patterns controlling human OA pathogenesis using single-cell RNA sequencing (scRNA-seq). METHODS: We performed unbiased transcriptome-wide scRNA-seq analysis,...
Topics
- Cartilage, Articular
- Chondrocytes
- Chondrogenesis
- Computational Biology
- Disease Progression
- Gene Expression Profiling
- Humans
- Osteoarthritis, Knee
- Phenotype
- Sequence Analysis, RNA