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Early induction of a prechondrogenic population allows efficient generation of stable chondrocytes from human induced pluripotent stem cells

25 Apr 2015

Abstract excerpt

Regeneration of human cartilage is inherently inefficient; an abundant autologous source, such as human induced pluripotent stem cells (hiPSCs), is therefore attractive for engineering cartilage. We report a growth factor-based protocol for differentiating hiPSCs into articular-like chondrocytes (hiChondrocytes) within 2 weeks, with an overall efficiency >90%. The hiChondrocytes are stable and comparable to adult...

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PMID: 25911615
DOI: 10.1096/fj.14-269720

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