Article

Oligogenic risk model for Gilles de la Tourette syndrome reveals a genetic continuum of tic disorders

2021-12-09

Abstract excerpt

Gilles de la Tourette syndrome (GTS) and other Tic Disorders (TDs) have a substantial genetic component with their heritability estimated at between 60 and 80%. Here we propose an oligogenic risk model of TDs using whole-genome sequencing (WGS) data from a group of Polish GTS patients, their families, and control samples (n = 278). The model is based on the overrepresentation of coding and non-coding genetic varia...

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Literature Corpus work: 085dd32f-348b-58b8-bdcd-3cae7edd7408
DOI: 10.1101/2021.12.09.21266782

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