Article
Elevated common variant genetic risk for tourette syndrome in a densely-affected pedigree.
Molecular psychiatry - 1 Dec 2021
Halvorsen Matthew, Szatkiewicz Jin, Mudgal Poorva, Yu Dongmei, Nordsletten Ashley E, Mataix-Cols David, Mathews Carol A, Scharf Jeremiah M, Mattheisen Manuel, Robertson Mary M, McQuillin Andrew, Crowley James J
Abstract excerpt
Tourette syndrome (TS) is a highly heritable neuropsychiatric disorder with complex patterns of genetic inheritance. Recent genetic findings in TS have highlighted both numerous common variants with small effects and a few rare variants with moderate or large effects. Here we searched for genetic causes of TS in a large, densely-affected British pedigree using a systematic genomic approach. This pedigree spans...
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