Article
Familial Risks of Tourette Syndrome and Chronic Tic Disorders. A Population-Based Cohort Study.
JAMA psychiatry - 1 Aug 2015
Mataix-Cols David, Isomura Kayoko, Pérez-Vigil Ana, Chang Zheng, Rück Christian, Larsson K Johan, Leckman James F, Serlachius Eva, Larsson Henrik, Lichtenstein Paul
Abstract excerpt
IMPORTANCE: Tic disorders, including Tourette syndrome (TS) and chronic tic disorders (CTDs), are assumed to be strongly familial and heritable. Although gene-searching efforts are well under way, precise estimates of familial risk and heritability are lacking. Previous controlled family studies were small and typically conducted within specialist clinics, resulting in potential ascertainment biases. They were...
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