Article
Whole-exome sequencing identifies high-confidence genes for tic disorders in a Chinese Han population.
Clinica chimica acta; international journal of clinical chemistry - 15 Jul 2024
Lu Qing, Zhou Yong, Qian Qiaoqiao, Chen Zhigang, Tan Qianqian, Chen Haiyun, Yin Fan, Wang Yue, Liu Zhisheng, Tian Peichao, Sun Dan
Abstract excerpt
BACKGROUND: Tic disorder (TD) is a polygenic neurodevelopmental disorder with high susceptibility. However, identifying high-confidence risk genes has been challenging due to poor replication across multiple studies. METHODS: Whole-exome sequencing was performed on 390 TD patients and 372 unaffected individuals in a Chinese Han population. Analysis of variance, burden analysis and in silico prediction were used...
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