Article

Progranulin deficiency perturbs lipid metabolism in white matter microglia

2026-07-28

Abstract excerpt

Progranulin (PGRN) deficiency is a common hallmark in frontotemporal dementia (FTD) patients with granulin ( GRN ) mutations (FTD- GRN ). Previous studies by our group and others have observed that reduced PGRN perturbs lysosomal function and microglial activation, which is believed to accelerate neurodegeneration in FTD- GRN patients. Lysosomal function is intrinsically linked to lipid metabolism, and evidence...

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Literature Corpus work: f7f9007d-c615-5e31-8f32-591c004f0e33
DOI: 10.64898/2026.07.27.740601

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