Back to search

Article

Exploration of interethnic variation and repurposed drug efficacy in the treatment of SARS-CoV-2 Infection (COVID-19)

2021-03-08

Abstract excerpt

<h4>ABSTRACT</h4> The COVID-19 global pandemic has led to repurposing of drugs, with little underlying evidence for treatment safety and efficacy. This may increase complications for patients with acute viral respiratory infections. UGT1A1 and CYP2D6 enzymes are involved in the metabolism of atazanavir and fluvoxamine repurposed for COVID-19. This study aimed to elucidate the role of interethnic variation in these...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
083ee8f1-5afa-58ea-a60b-581d6cf27bcd
DOI
10.1101/2021.03.07.21253095
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Exploration of interethnic variation and repurposed drug efficacy in the treatment of SARS-CoV-2 Infection (COVID-19)DOI 10.1101/2021.03.07.21253095
Frequencies of CYP2D6 genetic polymorphisms in Arab populations.Semantic proximity
Exploration of interethnic variation in the ibuprofen metabolizing enzyme CYP2C9: a cautionary guide for treatment of COVID-19 symptomsSemantic proximity
The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.Semantic proximity
Drug Metabolizing Enzymes: An Exclusive Guide into Latest Research in Pharmaco-genetic Dynamics in Arab CountriesSemantic proximity
Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness.Semantic proximity
Exploration of Interethnic Variation in the Ibuprofen Metabolizing Enzyme&nbsp;CYP2C9: A Cautionary Guide for Treatment of COVID-19 SymptomsSemantic proximity
Exploration of interethnic variation in the ibuprofen metabolizing enzyme CYP2C9: a genetic-based cautionary guide for treatment of COVID-19 symptomsSemantic proximity
Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations.Semantic proximity
Pharmacogenetic landscape of Metabolic Syndrome components drug response in Tunisia and comparison with worldwide populations.Semantic proximity
Genetic variants associated with warfarin dosage in Kuwaiti population.Semantic proximity
The variation landscape of CYP2D6 in a multi-ethnic Asian population.Semantic proximity
Differences in drug pharmacokinetics between East Asians and Caucasians and the role of genetic polymorphisms.Semantic proximity
Select a neighboring publication to make it the new centre.