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Article

The variation landscape of CYP2D6 in a multi-ethnic Asian population.

Scientific reports - 20 Jul 2024

Maulana Yusuf, Toro Jimenez Rodrigo, Twesigomwe David, Sani Levana, Irwanto Astrid, Bertin Nicolas, Gonzalez-Porta Mar

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) plays a crucial role in metabolizing approximately 20% of medications prescribed clinically. This enzyme is encoded by the CYP2D6 gene, known for its extensive polymorphism with over 170 catalogued haplotypes or star alleles, which can have a profound impact on drug efficacy and safety. Despite its importance, a gap exists in the global genomic databases, which are predominantly...

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Identifiers

PMID: 39030343
DOI: 10.1038/s41598-024-67691-6
PMCID: PMC11271511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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