Article
The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.
Disease markers - 1 Jan 2015
Wakil Salma M, Nguyen Cao, Muiya Nzioka P, Andres Editha, Lykowska-Tarnowska Agnieszka, Baz Batoul, Tahir Asma I, Meyer Brian F, Morahan Grant, Dzimiri Nduna
Abstract excerpt
BACKGROUND: The Affymetrix Drug Metabolizing Enzymes and Transporters (DMET) Plus Premier Pack has been designed to genotype 1936 gene variants thought to be essential for screening patients in personalized drug therapy. These variants include the cytochrome P450s (CYP450s), the key metabolizing enzymes, many other enzymes involved in phase I and phase II pharmacokinetic reactions, and signaling mediators...
Topics
- Arabs
- Cytochrome P-450 Enzyme System
- Gene Frequency
- Humans
- Polymorphism, Single Nucleotide