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Article

Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs

3 Oct 2024

Abstract excerpt

Background Major histocompatibility complex class-1-related protein (MR1), unlike human leukocyte antigen (HLA) class-1, was until recently considered to be monomorphic. MR1 presents metabolites in the context of host responses to bacterial infection. MR1-restricted TCRs specific to tumor cells have been described, raising interest in their potential therapeutic application for cancer treatment. The diversity of...

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PMID: 39445059
DOI: 10.3389/fonc.2024.1419528

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