Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Convergent epigenetic evolution drives relapse in acute myeloid leukemia.

eLife - 22 Apr 2024

Nuno Kevin, Azizi Armon, Koehnke Thomas, Lareau Caleb, Ediriwickrema Asiri, Corces M Ryan, Satpathy Ansuman T, Majeti Ravindra

Abstract excerpt

Relapse of acute myeloid leukemia (AML) is highly aggressive and often treatment refractory. We analyzed previously published AML relapse cohorts and found that 40% of relapses occur without changes in driver mutations, suggesting that non-genetic mechanisms drive relapse in a large proportion of cases. We therefore characterized epigenetic patterns of AML relapse using 26 matched diagnosis-relapse samples with...

Topics

Leukemia, Myeloid, Acute
Humans
Epigenesis, Genetic
Recurrence
Mutation
Evolution, Molecular
Chromatin
Neoplastic Stem Cells

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38647535
DOI: 10.7554/eLife.93019
PMCID: PMC11034943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Convergent epigenetic evolution drives relapse in acute myeloid leukemia.PMID 38647535Read ↗

Genomic and evolutionary portraits of disease relapse in acute myeloid leukemiaSemantic proximity Read ↗

Late relapse in acute myeloid leukemia (AML): clonal evolution or therapy-related leukemia?Semantic proximity Read ↗

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencingSemantic proximity Read ↗

Multi-omics analysis of longitudinal patient samples reveals the molecular mechanism of AML progressionSemantic proximity Read ↗

Multi-omic analysis of longitudinal acute myeloid leukemia patient samples reveals potential prognostic markers linked to disease progressionSemantic proximity Read ↗

Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia.Semantic proximity Read ↗

Clonal Evolution of Pediatric Acute Myeloid Leukemia and Its Contribution to Disease RelapseSemantic proximity Read ↗

Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia.Semantic proximity Read ↗

Biology of post-transplant relapse: actionable features.Semantic proximity Read ↗

Comprehensive analysis of mutations and clonal evolution patterns in a cohort of patients with cytogenetically normal acute myeloid leukemiaSemantic proximity Read ↗

Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemiaSemantic proximity Read ↗

Genetic and epigenetic heterogeneity and the impact on cancer relapse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.