Article

Role of microRNAs and effects of substrate, age and stretch in experimental models for IPF

2020-01-01

Abstract excerpt

Pulmonary fibrosis (IPF) is a debilitating progressive disease mostly affecting the elderly, and due to dysregulated wound healing repair. It is characterised by increased matrix production and altered ECM composition, leading to increased tissue rigidity, and eventually, death. In mammalian lungs, mechanical stretch is generated by the diaphragm and chest muscles and transferred first to lung septa and then at ce...

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Literature Corpus work: 082de4e5-9bc5-5775-af06-c2592ef7ddec
DOI: 10.17638/03131368

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