Article

A common molecular logic determines embryonic stem cell self-renewal and reprogramming

2017-10-10

Abstract excerpt

During differentiation and reprogramming new cell identities are generated by reconfiguration of gene regulatory networks. Here we combined automated formal reasoning with experimentation to expose the logic of network activation during induction of naïve pluripotency. We find that a Boolean network architecture defined for maintenance of naïve state embryonic stem cells (ESC) also explains transcription factor be...

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Identifiers and source

Literature Corpus work: 07e52aa0-22ad-53e8-a301-b9dc67fff4c4
DOI: 10.1101/200501

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