Article

Attractors are less stable than their basins: Canalization creates a coherence gap in gene regulatory networks

2025-11-08

Abstract excerpt

Waddington’s epigenetic landscape has served as biology’s central metaphor for cellular differentiation for over half a century, depicting mature cell types as balls resting in stable valley floors. Boolean networks – introduced by Kauffman in 1969 to model gene regulatory dynamics – provide a mathematical formalization of this landscape, where attractors represent phenotypes and basins of attraction correspond to...

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Literature Corpus work: f4141e5a-65f5-51b9-a70d-2f39722ff6c7
DOI: 10.1101/2025.11.06.687062

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