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Gasdermin D is activated but does not drive neurodegeneration in SOD1 <sup>G93A</sup> model of ALS: Implications for targeting pyroptosis

2024-10-12

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron loss, microgliosis, and neuroinflammation. While pyroptosis, an inflammatory form of programmed cell death, has been implicated in ALS, the specific role of Gasdermin D (GSDMD) – the primary executioner of pyroptosis – remains unexplored. In this study, we examined the function of GSDMD in the well-es...

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Literature Corpus work
07d47936-baf5-59e6-89bc-213f46ff7f63
DOI
10.1101/2024.10.10.617609
Open publication

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Gasdermin D is activated but does not drive neurodegeneration in SOD1 <sup>G93A</sup> model of ALS: Implications for targeting pyroptosisDOI 10.1101/2024.10.10.617609
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