Article

Mosaic CDKL5 expression in heterozygous female mice is associated with age- and region- dependent remodeling of inhibitory circuits

2026-05-30

Abstract excerpt

<title>Abstract</title> CDKL5 Deficiency Disorder (CDD) is a severe X-linked encephalopathy that predominantly affects heterozygous females, in whom random X-chromosome inactivation generates mosaic CDKL5 expression. Although early-onset epilepsy is a hallmark of the disorder, the mechanisms by which mosaic CDKL5 loss destabilizes neural circuits over time remain poorly understood. Here, we demonstrate a dyn...

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Literature Corpus work: f6f1cf53-cca8-592f-83c0-e251f2cd00c3
DOI: 10.21203/rs.3.rs-9792299/v1

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