Article

Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome

2021-06-15

Abstract excerpt

<h4>SUMMARY</h4> Defects in interneuron migration during forebrain development can disrupt the assembly of cortical circuits and have been associated with neuropsychiatric disease. The molecular and cellular bases of such deficits have been particularly difficult to study in humans due to limited access to functional forebrain tissue from patients. We previously developed a human forebrain assembloid model of Tim...

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Literature Corpus work: e4e5285e-7d74-526e-8127-22d7831a9d0e
DOI: 10.1101/2021.06.14.448277

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