Dorsal telencephalon‐specific <i>RA‐GEF‐1</i> knockout mice develop heterotopic cortical mass and commissural fiber defect

Abstract excerpt

Neural migration defects lead to various types of human malformations of cortical development including subcortical band heterotopia, which shows formation of a secondary cortical plate beneath the primary cortex and is typically caused by mutation of the DCX (doublecortin) gene. Subcortical band heterotopia is usually associated with mental retardation and epilepsy. We previously discovered RA-GEF-1 as a guanine...

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