Article

Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome

2022-08-31

Abstract excerpt

The correct development and activity of neurons and glial cells is necessary to establish proper brain connectivity. DYRK1A encodes a protein kinase involved in the neuropathology associated with Down syndrome that influences neurogenesis and the morphological differentiation of neurons. DYRK1A loss-of-function mutations in heterozygosity cause a well-recognizable syndrome of intellectual disability and autism spe...

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Literature Corpus work: 36b44731-0f84-56b3-9661-986c5a87c2b3
DOI: 10.21203/rs.3.rs-1993656/v1

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