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Article

Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2014

Li June, Kurasawa Yasuhiro, Wang Yang, Clise-Dwyer Karen, Klumpp Sherry A, Liang Hong, Tailor Ramesh C, Raymond Aaron C, Estrov Zeev, Brandt Stephen J, Davis Richard E, Zweidler-McKay Patrick, Amin Hesham M, Nagarajan Lalitha

Abstract excerpt

Transcriptional mechanisms governing hematopoietic stem cell (HSC) quiescence, self-renewal, and differentiation are not fully understood. Sequence-specific ssDNA-binding protein 2 (SSBP2) is a candidate acute myelogenous leukemia (AML) suppressor gene located at chromosome 5q14. SSBP2 binds the transcriptional adaptor protein Lim domain-binding protein 1 (LDB1) and enhances LDB1 stability to regulate gene...

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Source

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Identifiers

PMID: 25238756
DOI: 10.4049/jimmunol.1300337
PMCID: PMC4201964

Genes

SSBP2
LDB1
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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