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Article

YY1 is indispensable for Lgr5 <sup>+</sup> intestinal stem cell renewal

12 May 2014

Abstract excerpt

The intestinal stem cell fuels the highest rate of tissue turnover in the body and has been implicated in intestinal disease and cancer; understanding the regulatory mechanisms controlling intestinal stem cell physiology is of great importance. Here, we provide evidence that the transcription factor YY1 is essential for intestinal stem cell renewal. We observe that YY1 loss skews normal homeostatic cell turnover,...

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PMID: 24821761
DOI: 10.1073/pnas.1400128111

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