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Article

Age-related dysfunction of the DNA damage response in intestinal stem cells

25 Apr 2019

Abstract excerpt

BACKGROUND: Senescence increases the risks of inflammatory bowel diseases and colon cancer. Intestinal stem cells (ISCs) in crypts differentiate into epithelial cells and thereby maintain intestinal homeostasis. However, the influence of aging on the functions of ISCs is largely unknown. The mutation rate is highest in the small and large intestines. Numerous types of naturally occurring DNA damage are removed by...

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PMID: 31057688
DOI: 10.1186/s41232-019-0096-y

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