Article

Transcriptome of the murine duodenum during recovery after a lethal dose of total body irradiation

2024-11-27

Abstract excerpt

In the aftermath of 9/11, the radiobiology community sought novel radiation mitigators capable of preventing death when administered 24 hours or later after exposure to lethal ionizing radiation. The survival and expansion of normal stem cells are crucial for restoring tissue integrity in time to prevent mortality. While FDA-approved drugs for acute radiation syndrome primarily target the hematopoietic system, res...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 83fb4ee0-2288-5b9c-8813-1d99030bce38
DOI: 10.1101/2024.11.26.625550

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptome of the murine duodenum during recovery after a lethal dose of total body irradiationDOI 10.1101/2024.11.26.625550Read

Modulation of radiation-induced intestinal injury by radioprotective agents: a cellular and molecular perspectivesSemantic proximity Read

Single-cell RNA sequencing of intestinal crypts reveals vital events in damage repair and the double-edged sword effect of the Wnt3/β-catenin pathway in irradiated miceSemantic proximity Read

<em>Drosophila melanogaster</em> as a Model of Gastrointestinal Radiation Injury Studies: Conserved Mechanisms, Experimental Approaches, and Countermeasure DiscoverySemantic proximity Read

LGR5+ Intestinal Stem Cells Display Sex Dependent RadiosensitivitySemantic proximity Read

p53 promotes revival stem cells in the regenerating intestine after severe radiation injurySemantic proximity Read

Trichostatin A mitigates acute and late effects of radiation in intestine by regulation of DNA damage repair and Wnt/TGFβ/Smad signalingSemantic proximity Read

LGR5+ Intestinal Stem Cells Display Sex Dependent RadiosensitivitySemantic proximity Read

Targeting Autophagy Accelerates Intestinal Repair after Acute Ionizing RadiationSemantic proximity Read

Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in miceSemantic proximity Read

Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survivalSemantic proximity Read

LGR5+ Intestinal Stem Cells Display Sex-Dependent RadiosensitivitySemantic proximity Read

MIIST305 mitigates gastrointestinal acute radiation syndrome injury and ameliorates radiation-induced gut microbiome dysbiosisSemantic proximity Read