Article
Multi-omics-guided characterization of neoantigens improves patient stratification and potentiates combinatorial immunotherapy in glioma.
Cell reports - 23 Dec 2025
Ma Yingying, Cai Yangyang, Yang Jiaxin, Zhao Zheng, Chen Zefeng, Lv Dezhong, Yu Jiaxin, Yang Changbo, Liu Kefan, Zeng Mengqian, Guo Han, Xu Kang, Jiang Qinghua, Yin Hang, Xu Juan, Li Yongsheng
Abstract excerpt
The identification of tumor-derived neoantigens that elicit an immune response has led to significant advancements in cancer immunotherapy. We comprehensively investigated the neoantigen atlas in Chinese glioma patients via the integration of whole-exome sequencing, transcriptome, and ribosome profiling. We further proposed MINER (Multi-omics Integration for NEoantigen Recognition) to prioritize neoantigens that...
Read the complete abstract on PubMedTopics
- Humans
- Glioma
- Immunotherapy
- Antigens, Neoplasm
- Brain Neoplasms
- Mutation