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Article

The cancer exome generated by alternative mRNA splicing dilutes predicted HLA class I epitope density.

PloS one - 1 Jan 2012

Stranzl Thomas, Larsen Mette V, Lund Ole, Nielsen Morten, Brunak Søren

Abstract excerpt

Several studies have shown that cancers actively regulate alternative splicing. Altered splicing mechanisms in cancer lead to cancer-specific transcripts different from the pool of transcripts occurring only in healthy tissue. At the same time, altered presentation of HLA class I epitopes is frequently observed in various types of cancer. Down-regulation of genes related to HLA class I antigen processing has been...

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Identifiers

PMID: 23049726
DOI: 10.1371/journal.pone.0038670
PMCID: PMC3458037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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