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Article

Deciphering the role of alternative splicing in neoplastic diseases for immune-oncological therapies

26 Apr 2024

Abstract excerpt

Alternative splicing (AS) is an important molecular biological mechanism regulated by complex mechanisms involving a plethora of cis and trans-acting elements. Furthermore, AS is tissue specific and altered in various pathologies, including infectious, inflammatory, and neoplastic diseases. Recently developed immuno-oncological therapies include monoclonal antibodies (mAbs) and chimeric antigen receptor (CAR) T...

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PMID: 38736877
DOI: 10.3389/fimmu.2024.1386993

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