Article

Evaluating the efficacy of enzalutamide and the development of resistance in a preclinical mouse model of type-I endometrial carcinoma

2019-12-12

Abstract excerpt

Androgen Receptor (AR) signaling is a critical driver of hormone-dependent prostate cancer and has also been proposed to have biological activity in female hormone-dependent cancers, including type I endometrial carcinoma (EMC). In this study, we evaluated the preclinical efficacy of a third-generation AR antagonist, enzalutamide, in a genetic mouse model of EMC, Sprr2f-Cre;Pten fl/fl . In this model, ablation o...

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Identifiers and source

Literature Corpus work: 078bf808-c17a-5307-8122-d265ba5d3b55
DOI: 10.1101/2019.12.06.868182

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