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Article

Non-canonical AR activity facilitates endocrine resistance in breast cancer

17 Dec 2018

Abstract excerpt

The role of androgen receptor (AR) in endocrine-resistant breast cancer is controversial and clinical trials targeting AR with an AR antagonist (e.g., enzalutamide) have been initiated. Here, we investigated the consequence of AR antagonism using in vitro and in vivo models of endocrine resistance. AR antagonism in MCF7-derived tamoxifen-resistant (TamR) and long-term estrogen-deprived breast cancer cell lines...

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PMID: 30557851
DOI: 10.1530/erc-18-0333

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