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Article

Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Sept 2016

Pusey Michelle, Bail Sophie, Xu Yan, Buiakova Olesia, Nestor Mariya, Yang Jing-Jing, Rice Lyndi M

Abstract excerpt

Protein methylesterase 1 (PME-1) promotes cancerous phenotypes through the demethylation and inactivation of protein phosphatase 2A. We previously demonstrated that PME-1 overexpression promotes Akt, ERK, and may promote Wnt signaling and increases tumor burden in a xenograft model of endometrial cancer. Here, we show that covalent PME-1 inhibitors decrease cell proliferation and invasive growth in vitro but have...

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Identifiers

PMID: 27048286
DOI: 10.1007/s13277-016-5036-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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