Article

Constitutive Expression of the Progesterone Receptor Isoforms Promotes Hormone-Dependent Development of Ovarian Neoplasms

2019-10-24

Abstract excerpt

Abnormal expression of the progesterone receptor (PGR) isoforms, PGRA and PGRB, is often observed in women with reproductive tract cancer. To assess the importance of the PGR isoform ratio in the maintenance of the healthy reproductive tract, mice with Cre recombinase- activated PGRA and PGRB transgenes were bred with the PGR Cre mouse model to generate strains expressing either PGRA or PGRB in PGR positive tissu...

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Literature Corpus work: ab5c5d0c-4514-5f83-9ee8-9b3b5773bf7b
DOI: 10.1101/816934

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