Article

A DARPin Increases the Catalytic Activity of Botulinum Neurotoxin A1

2023-01-20

Abstract excerpt

<title>Abstract</title> <p>In this study, we characterized Designed Ankyrin Repat Proteins (DARPins) as investigative tools to probe botulinum neurotoxin (BoNT) function and as potential antidotes for botulism. We selected DARPins against the catalytic domain of BoNT/A1 and characterized them by biochemical, biophysical and structural studies in combination with functional assays in cultured neurons and muscle ti...

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Literature Corpus work: 076ceb42-0a0f-5791-b8b3-3a662e30fb88
DOI: 10.21203/rs.3.rs-2411408/v1

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