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Article

Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma

3 Mar 2022

Abstract excerpt

Abstract Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin lymphoma distinguished by the presence of clonal malignant T cells. The heterogeneity of malignant T cells and the complex tumor microenvironment remain poorly characterized. With single-cell RNA analysis and bulk whole-exome sequencing on 19 skin lesions from 15 CTCL patients, we decipher the intra-tumor and inter-lesion...

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PMID: 35241665
DOI: 10.1038/s41467-022-28799-3

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