Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity.

doi:10.1182/blood.2020009655

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Article

Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity.

Blood - 7 Oct 2021

Park Joonhee, Daniels Jay, Wartewig Tim, Ringbloom Kimberly G, Martinez-Escala Maria Estela, Choi Sara, Thomas Jane J, Doukas Peter G, Yang Jingyi, Snowden Caroline, Law Calvin, Lee Yujin, Lee Katie, Zhang Yancong, Conran Carly, Tegtmeyer Kyle, Mo Samuel H, Pease David R, Jothishankar Balaji, Kwok Pui-Yan, Abdulla Farah R, Pro Barbara, Louissaint Abner, Boggon Titus J, Sosman Jeffrey, Guitart Joan, Rao Deepak, Ruland Jürgen, Choi Jaehyuk

Abstract excerpt

Cutaneous T-cell lymphomas (CTCLs) are a clinically heterogeneous collection of lymphomas of the skin-homing T cell. To identify molecular drivers of disease phenotypes, we assembled representative samples of CTCLs from patients with diverse disease subtypes and stages. Via DNA/RNA-sequencing, immunophenotyping, and ex vivo functional assays, we identified the landscape of putative driver genes, elucidated...

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Identifiers

PMID: 34115827
DOI: 10.1182/blood.2020009655
PMCID: PMC8499046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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